An experimental study was conducted to evaluate the cardiotoxic effects in the progeny of dams treated with methimazole, monocrotophos and lead acetate. Female pregnant albino rats of Wistar Kyoto strain were divided into 5 groups and treated as follows from the day 3 of pregnancy till weaning of pups on post-natal day (PND) 21: Group 1 served as sham control, 2 received methimazole @ 0.02% in drinking water, 3 received monocrotophos (MCP; 0.3 mg/kg orally), 4 received lead acetate @ 0.2% in drinking water and 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14th day of gestation in dams. Eight pups from each group were euthanized on PND 21 and 90, and heart tissues were collected for analysis. TBARS, protein carbonyls and GSH of heart were studied on PND 21 and 90, while the lipid profile, lactate dehydrogenase (LDH) and troponins in serum, and the activity of Na+/K+ ATPase and Mg2+ATPase in the heart were studied on PND 90. T3, T4, HDL cholesterol, GSH, Na+ K+ ATPase and Mg2+ATPase were significantly (P < 0.05) decreased, while TSH, TBARS, protein carbonyls, total cholesterol, triglycerides, serum LDH and serum troponins were significantly (P < 0.05) increased in all the test groups as compared to group 1. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland of dams as the thyroid profile was altered significantly and the cardiotoxic effects were comparable to those induced by methimazole.
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